HRGM_Genome_4863 - 2 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

c00010_HRGM_G.. (original name was: HRGM_Genome_4863_10) (Genus species)

Region	Type	From	To	Most similar known cluster		Similarity
Region 10.1	NRPS,T1PKS	1	61,914

c00020_HRGM_G.. (original name was: HRGM_Genome_4863_20) (Genus species)

Region	Type	From	To	Most similar known cluster		Similarity
Region 20.1	sactipeptide	35,086	55,223

Region	Type	From	To	Most similar known cluster	Similarity
Region 10.1	NRPS,T1PKS	1	61,914
Region 20.1	sactipeptide	35,086	55,223

No secondary metabolite regions were found in these records:: c00001_HRGM_G.. (original name was: HRGM_Genome_4863_1) (Genus species); c00002_HRGM_G.. (original name was: HRGM_Genome_4863_2) (Genus species); c00003_HRGM_G.. (original name was: HRGM_Genome_4863_3) (Genus species); c00004_HRGM_G.. (original name was: HRGM_Genome_4863_4) (Genus species); c00005_HRGM_G.. (original name was: HRGM_Genome_4863_5) (Genus species); c00006_HRGM_G.. (original name was: HRGM_Genome_4863_6) (Genus species); c00007_HRGM_G.. (original name was: HRGM_Genome_4863_7) (Genus species); c00008_HRGM_G.. (original name was: HRGM_Genome_4863_8) (Genus species); c00009_HRGM_G.. (original name was: HRGM_Genome_4863_9) (Genus species); c00011_HRGM_G.. (original name was: HRGM_Genome_4863_11) (Genus species); c00012_HRGM_G.. (original name was: HRGM_Genome_4863_12) (Genus species); c00013_HRGM_G.. (original name was: HRGM_Genome_4863_13) (Genus species); c00014_HRGM_G.. (original name was: HRGM_Genome_4863_14) (Genus species); c00015_HRGM_G.. (original name was: HRGM_Genome_4863_15) (Genus species); c00016_HRGM_G.. (original name was: HRGM_Genome_4863_16) (Genus species); c00017_HRGM_G.. (original name was: HRGM_Genome_4863_17) (Genus species); c00018_HRGM_G.. (original name was: HRGM_Genome_4863_18) (Genus species); c00019_HRGM_G.. (original name was: HRGM_Genome_4863_19) (Genus species); c00021_HRGM_G.. (original name was: HRGM_Genome_4863_21) (Genus species); c00022_HRGM_G.. (original name was: HRGM_Genome_4863_22) (Genus species); c00023_HRGM_G.. (original name was: HRGM_Genome_4863_23) (Genus species); c00024_HRGM_G.. (original name was: HRGM_Genome_4863_24) (Genus species); c00025_HRGM_G.. (original name was: HRGM_Genome_4863_25) (Genus species); c00026_HRGM_G.. (original name was: HRGM_Genome_4863_26) (Genus species); c00027_HRGM_G.. (original name was: HRGM_Genome_4863_27) (Genus species); c00028_HRGM_G.. (original name was: HRGM_Genome_4863_28) (Genus species); c00029_HRGM_G.. (original name was: HRGM_Genome_4863_29) (Genus species); c00030_HRGM_G.. (original name was: HRGM_Genome_4863_30) (Genus species); c00031_HRGM_G.. (original name was: HRGM_Genome_4863_31) (Genus species); c00032_HRGM_G.. (original name was: HRGM_Genome_4863_32) (Genus species); c00033_HRGM_G.. (original name was: HRGM_Genome_4863_33) (Genus species); c00034_HRGM_G.. (original name was: HRGM_Genome_4863_34) (Genus species); c00035_HRGM_G.. (original name was: HRGM_Genome_4863_35) (Genus species); c00036_HRGM_G.. (original name was: HRGM_Genome_4863_36) (Genus species); c00037_HRGM_G.. (original name was: HRGM_Genome_4863_37) (Genus species); c00038_HRGM_G.. (original name was: HRGM_Genome_4863_38) (Genus species); c00039_HRGM_G.. (original name was: HRGM_Genome_4863_39) (Genus species); c00040_HRGM_G.. (original name was: HRGM_Genome_4863_40) (Genus species)

Compact view

c00010_HRGM_G.. - Region 1 - NRPS,T1PKS

Download region GenBank file

Location: 1 - 61,914 nt. (total: 61,914 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: (cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

ClusterBlast

KnownClusterBlast

SubClusterBlast

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Similar known gene clusters

No matches found.

Similar subclusters

No matches found.

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 61914:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (X) + (mal) + (mal) + (mal) + (X) + (X) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

HRGM_Genome_4863_CDS_01331

Search NORINE for peptide: strict or relaxed

AMP-binding (24..424): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

HRGM_Genome_4863_CDS_01332

Search NORINE for peptide: strict or relaxed

AMP-binding (14..462): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DicDsGgVlK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 50% (weak)

HRGM_Genome_4863_CDS_01333

Search NORINE for peptide: strict or relaxed

PKS_AT (533..816): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 110.4
inactive: 77.3
Methylmalonyl-CoA: 43.6
Methoxymalonyl-CoA: 43.1
Isobutyryl-CoA: 32.1
Propionyl-CoA: 29.6
Benzoyl-CoA: 17.1
fatty_acid: 15.3
Acetyl-CoA: 14.6
CHC-CoA: 14.5
trans-1,2-CPDA: 10.4
2-Methylbutyryl-CoA: 9.7
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

AMP-binding (1442..1836): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLfNiSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 80% (moderate)

HRGM_Genome_4863_CDS_01344

PKS_AT (501..777): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 28.2
Methoxymalonyl-CoA: 25.1
inactive: 23.6
Methylmalonyl-CoA: 23.5
Isobutyryl-CoA: 12.1
2-Methylbutyryl-CoA: 11.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

HRGM_Genome_4863_CDS_01345

Search NORINE for peptide: strict or relaxed

AMP-binding (42..449): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLYsLgdIfK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 60% (weak)

HRGM_Genome_4863_CDS_01347

Search NORINE for peptide: strict or relaxed

AMP-binding (628..1043): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vgmWLGcSGK
Nearest Stachelhaus code:: alpha-hydroxy-isocaproic-acid
Stachelhaus code match:: 60% (weak)

HRGM_Genome_4863_CDS_01349

Search NORINE for peptide: strict or relaxed

AMP-binding (10..397): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: syryesTGAK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 40% (weak)

c00020_HRGM_G.. - Region 1 - sactipeptide

Download region GenBank file

Location: 35,086 - 55,223 nt. (total: 20,138 nt) Show pHMM detection rules used

sactipeptide: (subtilosin or thuricin or TIGR04404 or TIGR03973)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

ClusterBlast

KnownClusterBlast

SubClusterBlast

Sactipeptides

Similar gene clusters

Similar known gene clusters

No matches found.

Similar subclusters

No matches found.

Sactipeptide predictions

Sactipeptides - No core peptides found.

Sactipeptides

Core peptide predictions

No core peptides found.